The kit that is currently available contains sodium nitrite and sodium thiosulfate. Sodium nitrite 300 mg ampule or 10 mg/kg given IV for 3 to 5 minutes in adults. The pediatric dose is 0.2 mL/kg, not to exceed 10 mL in pediatric patients. The dose of sodium thiosulfate is one ampule or 12.5 grams in 50 mL, given intravenously for 30 minutes in adults. The dose for pediatric patients is 7 g/m2 and not to exceed 12.5 grams. Hyperbaric oxygen treatment remains controversial due to inconsistent findings in the literature overall. Two animal studies did show some improvement in hyperbaric oxygen in addition to antidotal therapy. The key to managing cyanide toxicity is patient education. Healthcare workers that include nurses, pharmacists, and physicians, need to educate the public about the dangers of cyanide in the workplace.
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